How to Use major depression in a Sentence

major depression

noun
  • Some show signs of major depression, which can lead to suicidal ideation or attempts.
    — Arian Campo-Flores and Melanie Grayce West, WSJ, 15 July 2018
  • Those who have had more than one episode of major depression might require longer treatment, but again, this isn’t a hard-and-fast rule.
    — SELF, 18 Nov. 2019
  • My wife suffers from major depression.
    — Abigail Van Buren, Boston Herald, 31 Jan. 2026
  • One potential factor for the quick jump in major depression rates among teens and kids is increased screen time.
    — Brett Molina, USA TODAY, 11 May 2018
  • Women are diagnosed with major depression at double the rate of men.
    — Ashley Welch, CBS News, 11 May 2018
  • Some reactions are normal, but major depression symptoms last at least two weeks.
    — Joe Carlson, Star Tribune, 27 Dec. 2020
  • My psychiatrist told me major depression changes the logic of your brain.
    — Danielle Tcholakian, The Cut, 12 Apr. 2018
  • Symptoms may be similar to that of mild major depression, where a person has few signs of depression.
    — Karen Pallarito, Health, 12 June 2024
  • That cycle’s upswing peaked in the mid-1970s, but this time, there was no major depression.
    — Mark Blyth, Foreign Affairs, 13 June 2016
  • Our adoptive father was abusive, and our mother had her own share of issues stemming from major depression.
    — Annie Lane, oregonlive, 16 June 2021
  • It’s estimated that one-in-three women and one-in-five men have an episode of major depression by the age of 65.
    — Big Think, 24 June 2024
  • The report found 60% of youth with major depression did not receive mental health treatment.
    — Mary Kekatos, ABC News, 8 May 2023
  • Super, 59, has been open about her struggle with major depression, an issue she’s written about.
    — Judith Graham, Fortune Well, 28 Nov. 2023
  • Arguably major depression has more consistent biomarkers than any of the others.
    — Patrick Skerrett, STAT, 3 Aug. 2024
  • People with major depression can develop blood pressure issues and may be more likely to have a heart attack.
    — Sandee Lamotte, CNN, 18 Sep. 2022
  • Unfortunately, this means that on top of having to save the world, many of them also now have to handle major depression.
    — Wired, 27 Nov. 2019
  • Less than 30% of Texas youth with major depression received mental health treatment.
    — Marin Wolf, Dallas News, 12 June 2023
  • Serotonin is involved in major depression and is the target of antidepressant drugs.
    — Rodrigo Pérez Ortega, Science | AAAS, 14 Feb. 2020
  • Self-doubt, insomnia, and intrusive thoughts are often the calling cards of major depression.
    — Donna Sarkar, Discover Magazine, 12 Feb. 2021
  • But a subset of patients can experience major depression during summer months because of the load heat puts on the brain.
    — Mark Prussin, CBS News, 29 June 2026
  • The psychiatrist and life coach was first diagnosed with major depression while in medical school.
    — Katie Dupere, Men's Health, 24 May 2022
  • His divorce in 2013 also led to major depression, his sentencing memo said.
    — Maxine Bernstein, OregonLive.com, 14 Feb. 2018
  • Schizophrenia, bipolar disorder, major depression and a host of others have no visible markers in the brain.
    — The Economist, 28 June 2018
  • In the grip of the low motivation that so often accompanies major depression, my patient has stopped cleaning her home.
    — Adrienne Lapidos, The Conversation, 1 July 2020
  • But it has long been approved as an anesthesia drug in kids and adults, and researchers were finalizing its approval as a treatment for major depression.
    — Katie Palmer, STAT, 5 Aug. 2021
  • Eighteen patients with major depression were treated with zalsupindole for one week in a monitored setting.
    — Clayton Dalton, New Yorker, 13 Mar. 2026
  • Their risk of major depression rose by about 16%, while there was no significant association among men.
    — Deirdre Bardolf, FOXNews.com, 18 Oct. 2025
  • At the same time, a history of major depression increases the risk of developing Alzheimer’s later in life.
    — Andrea Petersen, New York Times, 8 Dec. 2019
  • Sage had asked regulators to approve the drug as a treatment for both postpartum and major depression, the latter of which has a much larger sales potential.
    — Allison Deangelis Reprints, STAT, 8 Jan. 2024
  • In fact, long before Covid, 78% of psychiatrists had high levels of burnout, and more than 16% had major depression.
    — Jessica Gold, STAT, 24 Mar. 2023

Some of these examples are programmatically compiled from various online sources to illustrate current usage of the word 'major depression.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

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